RTW Investments
Period: Q4 2025 · Filed: 2026-02-17
AUM
$9.98B
Total portfolio value
Positions
91
Reported securities
Top Holding
MDGL
11.6% $1.16B
QoQ Changes
+8 / -8
new · exited
⚠️13F Filing Disclosure
AUM figures shown are calculated by summing the reported market value of all positions in SEC 13F-HR filings — not the fund's actual assets under management.
- Excludes cash, bonds, private equity, short positions, and foreign-listed stocks not required to be reported.
- For PUT and CALL options, the reported Value is the notional value of the underlying shares — not the option premium paid. This significantly overstates the actual capital at risk.
- Actual fund AUM is typically higher and includes strategies, instruments, and positions that never appear in a 13F.
- 13F filings cover institutional managers with ≥$100M in 13F securities. Positions reflect end-of-quarter holdings, disclosed up to 45 days after the period ends.
Data sourced from SEC EDGAR. This tracker is for informational purposes only and does not constitute investment advice.
Portfolio Holdings
Top 30 positions
⚠️ Performance % calculated from filing date ( 2026-02-17) shown is the underlying stock price movement — not the derivative's P&L.
| Ticker | Issuer | Notional | Port % | @ Filing | Now (EOD) | Since Filing | Allocation |
|---|---|---|---|---|---|---|---|
| MDGL | $1.16B | 11.63% | $582.34 | $528.10 | -9.3% | 11.6% | |
| INSM | $842.9M | 8.44% | $174.04 | $111.60 | -35.9% | 8.4% | |
| PTCT | $588.4M | 5.89% | $75.96 | $83.31 | +9.7% | 5.9% | |
| ARGX | $566.4M | 5.67% | $840.95 | $939.68 | +11.7% | 5.7% | |
| PTGX | $441.9M | 4.43% | $87.34 | $131.62 | +50.7% | 4.4% | |
| NTRA | $343.6M | 3.44% | $229.09 | $279.32 | +21.9% | 3.4% | |
| RDNT | $281.0M | 2.81% | $71.35 | $68.75 | -3.6% | 2.8% | |
| TARS | $273.1M | 2.74% | $81.88 | $65.44 | -20.1% | 2.7% | |
| COGT | $269.7M | 2.70% | $35.52 | $38.69 | +8.9% | 2.7% | |
| PEN | $269.4M | 2.70% | $310.91 | $318.57 | +2.5% | 2.7% | |
| IRTC | $209.7M | 2.10% | $177.44 | $126.48 | -28.7% | 2.1% | |
| APGE | $204.7M | 2.05% | $75.48 | $132.91 | +76.1% | 2.0% | |
| APLS | $192.6M | 1.93% | $25.12 | — | 1.9% | ||
| ACAD | $190.8M | 1.91% | $26.71 | $25.97 | -2.8% | 1.9% | |
| ESTA | $188.7M | 1.89% | $72.88 | $89.25 | +22.5% | 1.9% | |
| STOK | $176.1M | 1.76% | $31.74 | $32.70 | +3.0% | 1.8% | |
| RGEN | $174.3M | 1.75% | $163.86 | $142.40 | -13.1% | 1.8% | |
| CYTK | $172.9M | 1.73% | $63.54 | $86.49 | +36.1% | 1.7% | |
| IMCR | $169.0M | 1.69% | $34.71 | $32.50 | -6.4% | 1.7% | |
| AXSM | $162.2M | 1.62% | $182.64 | $244.31 | +33.8% | 1.6% | |
| GH | $151.3M | 1.52% | $102.14 | $167.98 | +64.5% | 1.5% | |
| NBIX | $150.6M | 1.51% | $141.83 | $174.26 | +22.9% | 1.5% | |
| SYRE | $136.7M | 1.37% | $32.76 | $86.63 | +164.4% | 1.4% | |
| ZLAB | $122.8M | 1.23% | $17.64 | $19.12 | +8.4% | 1.2% | |
| IMTX | $120.0M | 1.20% | $10.50 | $9.95 | -5.2% | 1.2% | |
| BLTE | $114.4M | 1.15% | $159.96 | $146.63 | -8.3% | 1.1% | |
| URGN | $106.4M | 1.07% | $23.42 | $38.02 | +62.3% | 1.1% | |
| XNCR | $103.8M | 1.04% | $15.31 | $15.00 | -2.0% | 1.0% | |
| PODD | $92.3M | 0.92% | $284.24 | $164.48 | -42.1% | 0.9% | |
| TSHA | $90.2M | 0.90% | $5.50 | $6.53 | +18.7% | 0.9% |
Quarter-on-Quarter Activity
Q4 2025 vs. Q3 2025
New Positions (8)
| Ticker | Issuer | Notional | Since Filing |
|---|---|---|---|
| IRTC | $209.7M | -28.7% | |
| APLS | $192.6M | ||
| RGEN | $174.3M | -13.1% | |
| PODD | $92.3M | -42.1% | |
| CSTL | $82.3M | ||
| IMVT | $80.8M | ||
| CELC | $54.9M | ||
| KOD | $41.6M |
Exited Positions (8)
| Ticker | Issuer | Notional |
|---|---|---|
| RNAM | $495.5M | |
| AKRO | $260.1M | |
| MRUS | $190.7M | |
| DGX | $47.6M | |
| LENZ | $40.2M | |
| DYN | $36.6M | |
| ABVX | $29.7M | |
| GEHC | $29.6M |
Increased (8)
| Ticker | Issuer | Notional | Shares Δ | Since Filing |
|---|---|---|---|---|
| ZLAB | $45.1M | +203.7% | +8.4% | |
| ALUR | $2.0M | +131.7% | ||
| BLTE | $91.3M | +128.9% | -8.3% | |
| COGT | $219.9M | +119.0% | +8.9% | |
| INSM | $398.6M | +57.0% | -35.9% | |
| CRNX | $26.6M | +54.9% | ||
| WVE | $16.4M | +50.0% | ||
| RDNT | $66.4M | +39.9% | -3.6% |
Trimmed (8)
| Ticker | Issuer | Notional | Shares Δ | Since Filing |
|---|---|---|---|---|
| CRVS | $-16.3M | -83.3% | ||
| XGN | $-13.8M | -53.4% | ||
| SYK | $-95.0M | -50.0% | ||
| ISRG | $-33.2M | -50.0% | ||
| TSHA | $10.6M | -32.7% | +18.7% | |
| NTRA | $21.7M | -25.0% | +21.9% | |
| BBNX | $10.6M | -24.2% | ||
| CNTA | $-10.8M | -21.9% |