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Home/Hedge Funds/Avoro Capital Advisors/Q1 2023

Avoro Capital Advisors

Period: Q1 2023 Β· Filed: 2023-05-15
View on SEC EDGAR β†—
AUM
$6.75B
Total portfolio value
Positions
41
Reported securities
Top Holding
HZNP
11.3% $764.0M
QoQ Changes
+3 / -0
new Β· exited
⚠️13F Filing Disclosure

AUM figures shown are calculated by summing the reported market value of all positions in SEC 13F-HR filings β€” not the fund's actual assets under management.

  • Excludes cash, bonds, private equity, short positions, and foreign-listed stocks not required to be reported.
  • For PUT and CALL options, the reported Value is the notional value of the underlying shares β€” not the option premium paid. This significantly overstates the actual capital at risk.
  • Actual fund AUM is typically higher and includes strategies, instruments, and positions that never appear in a 13F.
  • 13F filings cover institutional managers with β‰₯$100M in 13F securities. Positions reflect end-of-quarter holdings, disclosed up to 45 days after the period ends.

Data sourced from SEC EDGAR. This tracker is for informational purposes only and does not constitute investment advice.

Portfolio Holdings

Top 30 positions

⚠️ Performance % calculated from filing date ( 2023-05-15) shown is the underlying stock price movement β€” not the derivative's P&L.
TickerIssuerNotionalPort %@ FilingNow (EOD)Since FilingAllocation
HZNPHORIZON THERAPEUTICS PLC$764.0M11.33%β€”β€”
11.3%
APLSAPELLIS PHARMACEUTICALS INC$732.9M10.87%$65.96β€”
10.9%
UTHRUNITED THERAPEUTICS CORP$642.8M9.53%$223.96$555.91+148.2%
9.5%
SRPTSAREPTA THERAPEUTICS INC$503.1M7.46%$137.83$19.28-86.0%
7.5%
ARGXARGENX SE$479.7M7.11%$372.58$939.68+152.2%
7.1%
MDGLMADRIGAL PHARMACEUTICALS INC$403.8M5.99%$242.26$528.10+118.0%
6.0%
BMRNBIOMARIN PHARMACEUTICAL INC$383.6M5.69%$97.24$58.99-39.3%
5.7%
SGENSEAGEN INC$364.8M5.41%β€”β€”
5.4%
ASNDASCENDIS PHARMA$356.5M5.29%$107.22$274.50+156.0%
5.3%
FOLDAMICUS THERAPEUTICS INC$302.8M4.49%β€”β€”
4.5%
ALNYALNYLAM PHARMACEUTICALS INC$221.3M3.28%$200.32$312.78+56.1%
3.3%
MRTXMIRATI THERAPEUTICS INC$206.6M3.06%β€”β€”
3.1%
XENEXENON PHARMACEUTICALS INC$175.4M2.60%$35.79$60.96+70.3%
2.6%
ISEEIVERIC BIO INC$165.4M2.45%β€”β€”
2.5%
KRYSKRYSTAL BIOTECH INC$140.1M2.08%$80.06$375.07+368.5%
2.1%
KYMRKYMERA THERAPEUTICS INC$114.2M1.69%$29.63$113.51+283.1%
1.7%
DICEDICE THERAPEUTICS INC$113.2M1.68%β€”β€”
1.7%
CBAYCYMABAY THERAPEUTICS INC$89.8M1.33%β€”β€”
1.3%
BCRXBIOCRYST PHARMACEUTICALS INC$86.9M1.29%$8.34$9.84+18.0%
1.3%
SNDXSYNDAX PHARMACEUTICALS INC$56.0M0.83%$21.12$21.82+3.3%
0.8%
NUVLNUVALENT INC$49.3M0.73%$26.09$123.73+374.2%
0.7%
IOVAIOVANCE BIOTHERAPEUTICS INC$42.9M0.64%$6.11$4.31-29.5%
0.6%
RNAMAVIDITY BIOSCIENCES INC$38.5M0.57%β€”β€”
0.6%
KURAKURA ONCOLOGY INC$38.0M0.56%$12.23$11.10-9.2%
0.6%
MNKDMANNKIND CORP$37.3M0.55%$4.10$4.52+10.2%
0.6%
GLUEMONTE ROSA THERAPEUTICS INC$33.7M0.50%$7.79$24.21+210.8%
0.5%
MRSNMERSANA THERAPEUTICS INC$31.0M0.46%β€”β€”
0.5%
RAREULTRAGENYX PHARMACEUTICAL INC$30.1M0.45%$40.10$33.47-16.5%
0.5%
MRNSMARINUS PHARMACEUTICALS INC$21.7M0.32%β€”β€”
0.3%
WHWKAADI BIOSCIENCES INC$20.6M0.31%$7.24$4.19-42.1%
0.3%

Quarter-on-Quarter Activity

Q1 2023 vs. Q4 2022

New Positions (3)

TickerIssuerNotional
VRCAVERRICA PHARMACEUTICALS INC$17.2M
MCRBSERES THERAPEUTICS INC$7.3M
XBICALLSPDR SERIES TRUST - S&P BIOTECH$0.2M

Exited Positions

None this quarter

Increased (8)

TickerIssuerNotionalShares Ξ”Since Filing
DICEDICE THERAPEUTICS INC$34.4M+56.4%
DSGNDESIGN THERAPEUTICS INC$-3.1M+54.0%
KRYSKRYSTAL BIOTECH INC$28.4M+24.1%+368.5%
RNAMAVIDITY BIOSCIENCES INC$-7.0M+22.4%
NUVLNUVALENT INC$3.0M+21.4%+374.2%
BCRXBIOCRYST PHARMACEUTICALS INC$-17.0M+15.1%+18.0%
SRPTCALLSAREPTA THERAPEUTICS INC$91.7M+15.0%-86.0%
BMRNBIOMARIN PHARMACEUTICAL INC$15.7M+11.0%-39.3%

Trimmed (4)

TickerIssuerNotionalShares Ξ”Since Filing
SRPTCALLSAREPTA THERAPEUTICS INC$-407.7M-92.1%-86.0%
ISEECALLIVERIC BIO INC$-142.7M-87.0%
AMLXAMYLYX PHARMACEUTICALS INC$-9.4M-24.9%
SGENSEAGEN INC$122.6M-4.4%
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